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2024, 28(1): 33-40 |
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Khalili N, Seyed Mohamadzad M H, Amiri S. The Relationship Between the Bilirubin Levels and Coronary Artery Disease in Patients With Stable Coronary Diseas. Hormozgan Medical Journal 2024; 28 (1) :33-40
URL: http://hmj.hums.ac.ir/article-1-2730-en.html
URL: http://hmj.hums.ac.ir/article-1-2730-en.html
Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Abstract: (95 Views)
Objectives: Coronary artery disease (CAD) is an atherosclerotic disease that is a major cause of mortality worldwide. Bilirubin has been considered an antioxidant that protects patients against atherosclerosis. Therefore, the present study examines the relationship between serum bilirubin levels with CAD.
Methods: In this cross-sectional, analytical study, the patients with suspected CAD were electively scheduled for angiography. Their blood samples were measured for total, direct, and indirect bilirubin levels. Following angiography, comparisons were made between the two groups of CAD and non-CAD subjects.
Results: Of 140 studied patients, 73(52.1%) were male and 67(47.9%) were female. The mean age of subjects was 55.32±10.71 years which was statistically significantly significant (P˂0.001). The mean total, direct, and indirect bilirubin levels between the groups were 0.74±0.57 (P=0.79), 0.22±0.07 (P=0.77), and 0.48±0.45 (P=0.77) mg/dL, respectively, which were not significant. The mean total (0.77±0.57 vs 0.71±0.57) and indirect bilirubin levels (0.53±0.53 vs 0.44±0.35) were higher in men than women and mean direct bilirubin was similar between men and women (0.23±0.07 vs 0.22±0.07). There was a statistically significant relationship between male and female groups in total and indirect bilirubin (P=0.05).
Discussion: No significant relationship was found between bilirubin levels and CAD either in terms of protective or aggravating role.
Methods: In this cross-sectional, analytical study, the patients with suspected CAD were electively scheduled for angiography. Their blood samples were measured for total, direct, and indirect bilirubin levels. Following angiography, comparisons were made between the two groups of CAD and non-CAD subjects.
Results: Of 140 studied patients, 73(52.1%) were male and 67(47.9%) were female. The mean age of subjects was 55.32±10.71 years which was statistically significantly significant (P˂0.001). The mean total, direct, and indirect bilirubin levels between the groups were 0.74±0.57 (P=0.79), 0.22±0.07 (P=0.77), and 0.48±0.45 (P=0.77) mg/dL, respectively, which were not significant. The mean total (0.77±0.57 vs 0.71±0.57) and indirect bilirubin levels (0.53±0.53 vs 0.44±0.35) were higher in men than women and mean direct bilirubin was similar between men and women (0.23±0.07 vs 0.22±0.07). There was a statistically significant relationship between male and female groups in total and indirect bilirubin (P=0.05).
Discussion: No significant relationship was found between bilirubin levels and CAD either in terms of protective or aggravating role.
Type of Study: Research |
Subject:
General
Received: 2023/05/22 | Accepted: 2023/06/5 | Published: 2024/01/1
Received: 2023/05/22 | Accepted: 2023/06/5 | Published: 2024/01/1
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