دوره 28، شماره 1 - ( 10-1402 )
جلد 28 شماره 1 صفحات 16-9 |
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AtashAbParvar A, Baniasadi M. Investigating Ki67 and p16 Positivity Pattern in Human Papillomavirus 16 and 18 Versus Other High-risk Human Papillomaviruses. Hormozgan Medical Journal 2024; 28 (1) :9-16
URL: http://hmj.hums.ac.ir/article-1-2727-fa.html
URL: http://hmj.hums.ac.ir/article-1-2727-fa.html
Investigating Ki67 and p16 Positivity Pattern in Human Papillomavirus 16 and 18 Versus Other High-risk Human Papillomaviruses. مجله پزشکی هرمزگان. 1402; 28 (1) :9-16
چکیده: (88 مشاهده)
Objectives: The expression of Ki67 and p16 has been used for the diagnosis of human papillomavirus (HPV) 16 and 18; however, limited research has been conducted on the comparison with other high-risk HPVs (HR-HPVs) in this respect. Accordingly, this study compares the positivity pattern of Ki67 and p16 in HPV16/18 with other HR-HPVs.
Methods: This descriptive study included women with positive screening test (Pap smear test) and positive HR-HPV referred to Shahid Mohammadi Hospital, Bandar Abbas, Iran, from 2018-2019 for colposcopy and cervical biopsy. Biopsy specimens were stained for Ki67 and p16. Data on age, education, and menopause status were also recorded.
Results: Of the 80 women included in this study with a mean age of 33.16±8.55 years, 48.8% had positive HPV16/18, and 51.2% were positive for other HR-HPVs. The positivity pattern of Ki67 and the type of HR-HPV (HPV16/18 vs other HR-HPVs) were significantly correlated (P=0.006). Full-thickness positive Ki67 was only observed in HPV16/18 positive specimens. Positive Ki67 in the upper and middle thirds were also significantly more frequent with HPV16/18. The correlation between positive Ki67 and HR-HPVs remained significant in women aged >30 years, with university education, and of childbearing age.
Discussion: The positivity pattern of Ki67 is significantly correlated with HPV16/18, and age, education, and menopause status are the influential factors. Meanwhile, the strongly positive p16 pattern was more frequent in HPV16/18 compared to other HR-HPVs; however, the relationship between the positivity pattern of p16 and the type of HR-HPV was not significant.
Methods: This descriptive study included women with positive screening test (Pap smear test) and positive HR-HPV referred to Shahid Mohammadi Hospital, Bandar Abbas, Iran, from 2018-2019 for colposcopy and cervical biopsy. Biopsy specimens were stained for Ki67 and p16. Data on age, education, and menopause status were also recorded.
Results: Of the 80 women included in this study with a mean age of 33.16±8.55 years, 48.8% had positive HPV16/18, and 51.2% were positive for other HR-HPVs. The positivity pattern of Ki67 and the type of HR-HPV (HPV16/18 vs other HR-HPVs) were significantly correlated (P=0.006). Full-thickness positive Ki67 was only observed in HPV16/18 positive specimens. Positive Ki67 in the upper and middle thirds were also significantly more frequent with HPV16/18. The correlation between positive Ki67 and HR-HPVs remained significant in women aged >30 years, with university education, and of childbearing age.
Discussion: The positivity pattern of Ki67 is significantly correlated with HPV16/18, and age, education, and menopause status are the influential factors. Meanwhile, the strongly positive p16 pattern was more frequent in HPV16/18 compared to other HR-HPVs; however, the relationship between the positivity pattern of p16 and the type of HR-HPV was not significant.
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