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Introduction: Prostatic adenocarcinoma is the most common malignancy of internal system and after lung cancer is the second cause of death in male. Genetic base of many neoplasms is related to suppressor tumor gene such as P53. Therefore, we aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with P53 staining method and its relationship with Gleason grade. Methods: In this cross-sectional study, during 2006 to 2008, all patients attending pathology ward of Shahid Mohammadi hospital with diagnosed prostatic adenocarcinoma enrolled for the study. Samples were stained with H & E staining and if adenocarcinoma was confirmed they stained with P53 stain using immunohistichmistry (IHC) method and severity of staining was recorded. We used colon cancer tissue for positive control and non tumoral prostate tissue for negative control. Data were analyzed using descriptive method and Chi-square test by means of SPSS. Results: 30 patients aged between 60 and 91 with mean age of 77.10±8.5 enrolled in the study. Grade of tumors vary from 2 to 10 and the most frequent grade was 7. Results show that with increase in the Gleason grade, intensity of P53 staining also increases. (P<0.001) Conclusion: Results demonstrated that there is a direct relationship between Gleason grade and intensity of P53 staining.

Keywords: Adenocarcinoma, P53, Prostate

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