MotamediRad N, Rezaeishamirzadi M, Moosavy S H, Shekari M. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis. Hormozgan Medical Journal 2016; 19 (6) :373-378
URL:
http://hmj.hums.ac.ir/article-1-1433-fa.html
MotamediRad Neda، Rezaeishamirzadi Meysam، Moosavy Seyyed Hamid، Shekari Mohammad. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis. مجله پزشکی هرمزگان. 1394; 19 (6) :373-378
URL: http://hmj.hums.ac.ir/article-1-1433-fa.html
چکیده: (33 مشاهده)
Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1B gene. Methods: 107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP. Results: There is no association between the presence of the T allele in an IL-1B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66, CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively. Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T polymorphism and peptic ulcer disease and chronic inflammation.
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عمومى دریافت: 1402/11/22