دوره 19، شماره 6 - ( 12-1394 )                   جلد 19 شماره 6 صفحات 378-373 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

MotamediRad N, Rezaeishamirzadi M, Moosavy S H, Shekari M. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis. Hormozgan Medical Journal 2016; 19 (6) :373-378
URL: http://hmj.hums.ac.ir/article-1-1433-fa.html
MotamediRad Neda، Rezaeishamirzadi Meysam، Moosavy Seyyed Hamid، Shekari Mohammad. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis. مجله پزشکی هرمزگان. 1394; 19 (6) :373-378

URL: http://hmj.hums.ac.ir/article-1-1433-fa.html


چکیده:   (33 مشاهده)
Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1B gene. Methods: 107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP. Results: There is no association between the presence of the T allele in an IL-1B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66, CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively. Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T polymorphism and peptic ulcer disease and chronic inflammation.
واژه‌های کلیدی: Polymorphism، Interleukin 1B، Peptic Ulcer، Gastritis
متن کامل [PDF 316 kb]   (70 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: 1402/11/22

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Hormozgan Medical Journal می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Hormozgan Medical Journal

Designed & Developed by : Yektaweb