Hormozgan medical journal. 2021;25(2): 85-89.
doi: 10.34172/hmj.2021.08
  Abstract View: 98
  PDF Download: 69

Health Sciences

Research Article

Effect of Eight Weeks of Resistance Training on PAX7 and MyoD in Fast and Slow-Twitch Skeletal Muscles of Old Rats

Hossein Esmaeili 1 ORCID logo, Javad Nemati 1* ORCID logo, Farhad Daryanoosh 1 ORCID logo, Mohammad Hemmatinafar 1 ORCID logo

1 Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran.
*Correspondence to Javad Nemati, Email: nemati_phy@yahoo. com


Background: Box 7 protein (PAX7) and myogenic differentiation (MyoD) proteins are the essential proteins to regulate the satellite cell and muscle hypertrophy.
Objectives: We aimed to investigate the effect of resistance training (RT) on PAX7 and MyoD in soleus and extensor digitorum longus (EDL) muscles of old rats.
Methods: In this experimental study, 12 old female rats were randomly divided into two groups including RT and control groups. The RT program was three days a week for eight weeks, in which the rats climbed a one-meter vertical ladder with 26 steps. The carried weights varied from 50% of body weight in the first week to 100% of body weight in the 8th week. Kolmogorov- Smirnov test and independent sample t test was used for statistical analysis (P≤0.05).
Results: MyoD protein in RT group significantly increased in soleus and EDL muscles compared with the control group (P=0.001). Also, Pax7 significantly increased in the soleus muscle in the RT group compared with control group (P=0.002); nevertheless, there was no significant difference in Pax7 protein in the EDL muscle between the RT and control groups (P=0.10).
Conclusion: RT can lead to proliferation and renewal of satellite cells in the soleus and EDL muscles by increasing PAX7 and MyoD proteins.
Keywords: Aging, Box 7 protein, Myogenic differentiation proteins, Exercise, Muscle
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Submitted: 22 Dec 2020
Accepted: 21 Jun 2021
ePublished: 29 Jun 2021
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