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Hormozgan medical journal. 2020;24(4): 107977.
doi: 10.5812/hmj.107977
  Abstract View: 137
  PDF Download: 72

COVID-19

Review Article

Neurological Involvement of Patients with COVID-19: Proposed Neuroinvasive Mechanisms and Management

Nahid Davoodian 1,2 ORCID logo, Maryam Arab Firouzjaei 3,4* ORCID logo, Ahmadagha Negahi 5

1 Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2 Department of Clinical Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3 Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4 Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
5 Department of Neurology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
* Corresponding author: Ph.D of Medical Physiology, Department of Physiology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Email: mfiruzjaee@gmail.com

Abstract

The novel Coronavirus Disease 2019 (COVID-19) is a highly contagious virus that has caused tremendous chaos in the world. Generally, respiratory symptoms are dominant manifestations in patients with COVID-19. However, the involvement of other organs, such as the nervous system has also been reported, which elucidates the capability of the virus to induce multi-organ failure. In this regard, the presentation of neurological symptoms in infected patients has raised the concern regarding the neuroinvasive potential of COVID-19. As of today, there is emerging evidence that supports the susceptibility of the nervous system to COVID-19. Undoubtedly, the awareness of these findings can result in the timely management and treatment of patients. In the present article, we documented a brief overview of neurological manifestations, possible neuroinvasion mechanisms of COVID-19, and the management of neurological symptoms in infected patients.

Keywords: COVID-19, Neurological Symptoms, Neuroinvasive
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Abstract View: 137

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Submitted: 27 Jul 2020
Accepted: 31 Aug 2020
ePublished: 27 Sep 2020
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