Hormozgan medical journal. 2021;25(1): 14-18.
doi: 10.5812/hmj.104835
  Abstract View: 84
  PDF Download: 66

Research Article

The Comparison of Serum Vitamin D Level in the Term Neonates With and Without Sepsis in Children Hospital of Bandar Abbas City, Iran From 2016 to 2017

Hossein Saadat 1 ORCID logo, Tayebe Mehrvari 2* ORCID logo, Rakhshaneh Goodarzi 1 ORCID logo, Fatemeh Kheiry 2 ORCID logo

1 Faculty of Medicine, Clinical Research Development Centre of Children’s Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2 Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
*Correspondence to Tayebe Mehrvari, Email: tmehrvari@gmail.com


Background: Neonatal sepsis is one of the most important causes of infant’s death, and the identification
of its factors has been the subject of many studies. Some new evidence suggested the role of vitamin D in
the occurrence of sepsis in infants.
Objectives: The aim of this study was to compare serum levels of vitamin D in neonates with sepsis in the
first week of birth and healthy neonates.
Methods: This case-control study was performed on 72 term neonates (36 neonates with sepsis as case and
36 healthy neonates as control group) who refereed to Bandar Abbas children’s hospitals, Bandar Abbas,
Iran, during 2016-2017.
Results: Serum vitamin D levels were measured in all infants and their mothers in both sepsis and control
groups. In addition, data collected, including sex, birth weight, C-reactive protein (CRP), and duration of
hospitalization in neonates with sepsis. Mean serum level of vitamin D was 18.52 ±11.49 ng/mL in sepsis
and 20.52 ±13.75 ng/mL in control group neonates (P≥0.05). The mean maternal serum level of vitamin
D in sepsis group was 22.44 ±11.26 ng/mL and in control group was 24.36 ±12.82 ng/mL (P≥0.05). There
was a positive correlation between maternal and neonatal vitamin D levels in the sepsis group (r=0.803)
and the control group (r=0.756). However, there was no significant difference between vitamin D level
and CRP (P=0.148) and length of stay (P=0.396) in the sepsis group.
Conclusion: Although the results of the present study showed a correlation between serums vitamin D
levels in mothers and neonates with neonatal sepsis, there was no significant vitamin D level between
neonates with and without sepsis.
Keywords: Serum Vitamin D, Sepsis, Neonate
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Submitted: 11 May 2020
Accepted: 04 Aug 2020
ePublished: 19 Nov 2020
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