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Hormozgan medical journal. 2021;25(1): 9-13.
doi: 10.5812/hmj.102085
  Abstract View: 54
  PDF Download: 37

Research Article

Serum Lipid Profile and Steroid Hormone Levels in Patients With Colorectal Cancer

Roya Abbasi Natajomrani 1, Durdi Qujeq 2* ORCID logo, Reza Hajihosseini 1, Vahid Hosseini 1

1 Department of Biology, Payame Noor University, Tehran, Iran
2 Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3 Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
*Correspondence to Durdi Qujeq, Email: dqujeq@gmail.com

Abstract

Background: Lipids are usually crucial to develop tumors, and dyslipidemia is correlated with the high chance of colon and colorectal cancer (CRC). Steroid hormones such as estrogen and progesterone can
decrease the risk of CRC development.
Objectives: The present study aimed to compare the serum levels of lipid profile and steroid hormones in
patients with CRC and healthy controls.
Methods: The present study included 40 consecutive adult patients with CRC in the Mazandaran Cancer
Center, Sari, Iran, between 2017 and 2020. The diagnosis of CRC was evaluated based on colonoscopy
with biopsy and CT scan. Also, the diagnosis of CRC was based on NCCN clinical practice guidelines
in oncology. Blood samples were taken before treatment during routine testing. A 5 mL of peripheral
blood was collected from each patient. All patients signed the written consent for the study. Also, a total
of 40 healthy subjects were selected as healthy controls from the same area during a routine physical
examination, which was also confirmed by screening colonoscopy and pathology. Serum total cholesterol
(TCH) and triglyceride (TG) levels were quantitatively determined by the colorimetric method. Low-density
lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined by
the turbidimetric immunoassay. Steroid hormones were quantitatively determined by the enzyme-linked
immunosorbent assay (ELISA) according to the reagent manufacturer’s instruction. To analyze data, the
SPSS software package (version 21) was applied.
Results: Among all the indicators studied, the mean ± SD of testosterone, follicle-stimulating hormone (FSH)
and luteinizing hormone (LH) levels was higher (1.85 ± 1.63 ng/mL, 15.35±0.13 mIU/L, 12.42±0.12.16
mIU/mL) in patients with CRC than healthy controls (0.40±.0.21 ng/mL, 6.27±0.50 mIU/mL, 2.89±0.20
mIU/mL, P<0.05 respectively). The results in subgroups showed that the mean testosterone (0.91±1.2
ng/L), FSH (19.11±16 mIU/mL) , LH (14.49±14 mIU/mL) levels in the female patients with CRC was higher
than healthy female controls and had more statistical significance(P=0.02, 0.00, 0.00), respectively. The
area under the AUC cure of the testosterone, FSH, and LH indicates positive test (0.670, 0.726 and 0.775).
Conclusion: Changes in the levels of steroid hormones and lipids could correlate with the elevated
chance of CRC. Therefore, assessment of multiple markers might overcome and provide better judgment
in patients with CRC.
Keywords: Colorectal cancer, DHEA, lipid profile, HDL-C, LDL-C, TG, Steroid hormones, Estradiol, Testosterone
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Submitted: 12 Apr 2020
Accepted: 03 Aug 2020
ePublished: 10 Nov 2020
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