Hormozgan medical journal. 2021;25(1): 3-8.
doi: 10.5812/hmj.102063
  Abstract View: 194
  PDF Download: 167

Research Article

Lipid Profile in Pregnant Women With and Without Gestational Diabetes Mellitus: A Case-Control Study

Zeynab Farsangi 1, Ghazal Zoghi 2, Masoumeh Kheirandish 2, Roghayeh Shahbazi 3, Masoumeh Mahmoudi 2, Mahmood Khayatian 4, Shahram Zare 5, Ladan Hajiabdolrassouli 2*

1 Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2 Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas Iran
3 Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada
4 Department of Biochemistry, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
5 Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
*Correspondence to Ladan Hajiabdolrassouli, Email: ladanhajiabdolrassouli98@ gmail.com


Background: Gestational diabetes mellitus (GDM), the most common metabolic disorder of pregnancy, is
associated with alterations in circulating lipids.
Objectives: The aim of this study was to compare lipid profiles in women with and without GDM.
Methods: This study was performed on 84 pregnant women at 26-30 weeks of gestation (42 pregnant
women with GDM as cases and 42 healthy pregnant women as controls). After obtaining informed consent
and gathering demographic data, subjects underwent a 75-g oral glucose tolerance test and lipid profile
was also measured in all subjects.
Results: We found that high-density lipoprotein (HDL) levels were significantly higher in the GDM group
(53.10±1.72 vs 46.64±1.70 mg/dL, P=0.008). Total cholesterol (228.96±52.03 vs 211.59±41.83 mg/
dL) and triglyceride (TG) levels (225.58±89.84 vs 208.38±80.66 mg/dL) were also higher in the GDM
group; however, the differences were not statistically significant (P=0.770 and P=0.327, respectively).
On the contrary, low-density lipoprotein was found to be non-significantly higher in the healthy group
(144.54±26.01 vs 122.41±4.82 mg/dL, P=0.709). Besides, there was a significant association between
HDL levels and GDM (OR: 1.049; 95% CI: 1.009-1.090, P=0.015). This association remained significant
when adjusted for age, body mass index (BMI), and gestational age (OR: 1.010; 95% CI: 1.002-1.017,
P=0.009). No significant association was found between GDM and TG, cholesterol, and LDL levels.
Conclusion: HDL levels are significantly higher in pregnant women with GDM compared to pregnant
women without GDM. HDL level is significantly associated with GDM even after adjustment for age, BMI,
and gestational age.
Keywords: Dyslipidemia, Gestational diabetes mellitus, Lipid profile, Pregnancy
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Submitted: 17 Mar 2020
Accepted: 06 Sep 2020
ePublished: 24 Nov 2020
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