Pain is neuroanatomically, psychologically and neurophysiologically complicated and its first function is protecting all alive creature body. This issue is so questionable and interesting that people who don’t feel pain how face this sensation and what problems threaten them. So many researchers by using 73 references, articles from electronical and library references have done a clinical study about CIPA which is a rare disorder of neuropathic disorders. These patients have no sensation toward pain and paiful stimulations and no sweating. This disorder has been occurred by genetic mutation and has been under study from 1996 to 2012. Which un health – care tream can reduce their complications by early diagnosis and thereaputic and preventive interventions.

واژه‌های کلیدی: Pain Insensitivity، Mutation، Sweating

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