Volume 21, Issue 1 (7-2017)                   hmj 2017, 21(1): 20-27 | Back to browse issues page



DOI: 10.18869/acadpub.hmj.21.1.20

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vafamand E, Bolboli L, Talebi A, Nematbakhsh M. The role of L-arginine and aerobic exercise in experimental renal ischemia reperfusion injury in male and female rats. hmj. 2017; 21 (1) :20-27
URL: http://hmj.hums.ac.ir/article-1-1691-en.html

Department of Physiology
Abstract:   (844 Views)

Introduction: Renal ischemia/reperfusion (I/R) injury due to reactive oxygen species (ROS) formation is the main cause of acute kidney damage. Nitric oxide (NO) biosynthesis and oxidative stress are closely related to the pathogenesis of renal I/R injury. This study was undertaken to determine the effects of L-arginine (L-arg) as NO donor and aerobic exercise (EX) and also the combination of L-arg with EX on renal I/R injury in male and female rats.

Methods: 54 male and female Wistar rats were divided into four groups in each gender as control, L-arginine (L-arg), treadmill exercise (EX), and L-arginine plus exercise (L-arg & EX). After 8 weeks of EX, animals were exposed to 45 min of bilateral kidney ischemia followed by 24 hours of reperfusion. We assessed serum creatinine (Cr), Kidney tissue damage score (KTDS), kidney weight (KW), serum nitrite and malondialdehyde (MDA) levels.

Results: L-arg, EX or combination of L-arg &EX caused a significant decrease in serum level of creatinine (Cr) (P<0.05). KTDS decreased significantly in all female treated groups and male L-arg treated group (P<0.05) when compared with the control group. However, the kidney weight was decreased significantly in male rats (P<0.05) at 24 hr post reperfusion, and such observation was not seen in female. No significant differences were detected in serum nitrite levels between the groups, but combination of L-arg &EX decreased the serum level of malondialdehyde (MDA) in female significantly (P<0.05).

Conclusion: Pretreatment with L-arg seems to have protective effects against renal I/R injury. The protective effect of exercise against renal I/R injury seems to be less than L-arg but the reno-protective effect of EX increases when combined with L-arg.

Keywords: Reperfusion, L-arginine, Aerobic Exercise
Citation: Vafamand E, Bolboli L, Talebi A, Nematbakhsh M. The role of L-arginine and aerobic exercise in experimental renal ischemia reperfusion injury in male and female rats. Hormozgan Medical Journal 2017;21(1):20-27.
Full-Text [PDF 572 kb]   (251 Downloads)    
Type of Study: Research | Subject: medical
Received: 2017/07/17 | Accepted: 2017/07/17 | Published: 2017/07/17

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Bimonthly Journal of Hormozgan University of Medical Sciences

Designed & Developed by : Yektaweb
Creative Commons License