Volume 21, Issue 1 (5-2017)                   hmj 2017, 21(1): 1-9 | Back to browse issues page

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Department of Physiology
Abstract:   (1592 Views)

Introduction: Acute kidney injury (AKI) has been known as a complex clinical complication in diabetic patients. The main cause of AKI is ischemia/reperfusion injury (IRI). This study was designed to investigate the protective effects of GABA on renal IRI in hyperglycemic female and male rats.

Methods: Sixty STZ induced diabetic male and female Wistar rats were categorized in 10 groups (5 female &5 male groups). Groups 1-3 in each gender received GABA (10, 50, 100µmol/kg/day) for 3 days, and then were subjected to renal IRI. Group 4 in each gender was subjected to renal IRI alone, and group 5 was subjected to surgical operation without renal IRI.24 hr after I/R injury, blood sample was obtained, and the animal were sacrificed for pathology investigation.

Results: Renal IRI alone increased the serum blood urea nitrogen levels (BUN) and creatinine (Cr), and kidney damage in both male and female rats significantly (P<0.05), however all doses of GABA decreased the serum BUN and Cr levels and tissue damage when compared with control group.

Conclusion: From the results of this study it seems that GABA administration in hyperglycemic rats could decrease renal injury after an ischemia/reperfusion.

Keywords: Ischemia, Reperfusion, Diabetes, GABA, Rat
Citation: Solatni N, Tighsaz Y, Nematbakhsh M. Renoprotective effects of GABA on ischemia/reperfusion- induced renal injury in hyperglycemia male and female rats. Hormozgan Medical Journal 2017;21(1):1-9.
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Type of Study: Research | Subject: medical
Received: 2017/07/17 | Accepted: 2017/07/17 | Published: 2017/07/17