Volume 19, Issue 4 (11-2015)                   hmj 2015, 19(4): 231-236 | Back to browse issues page


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Zangiabadi N, Jafari M, Shaabani M. Effect of Angipars on neuropathic pain in streptozotocin-induced diabetic rats. hmj. 2015; 19 (4) :231-236
URL: http://hmj.hums.ac.ir/article-1-1520-en.html

MSc Student of Biology Pharmaceutics Research Center
Abstract:   (1452 Views)

Introduction: Diabetes is the most common cause of peripheral nerve involvement. Evaluating the effect of antioxidants on diabetic neuropathic pain is important. This study aimed at evaluating the effects of Angipars medicine in the treatment of neuropathic hyperalgesia in single dose streptozotocin-induced diabetic rats.

Correspondence:

M. Jafari, MSc Student.

Pharmaceutics Research Center, Kerman University of Medical Sciences

Kerman, Iran

Tel:+98 9131965774

Email:

mandana.jafary@gmail.com

Methods: The study was performed on 50 Spraque dawley rats of 250-300 grams weight. The rats were divided into four groups of control, sham, Angipars-receiving diabetic, and vehicle-receiving diabetic, with at least 8 rats in each group. Diabetes was induced by intraperitoneal injection of 45 mg/kg streptozotocin dissolved in a 0.05 M citrate buffer. After confirming the diabetes, the diabetic rats received (5, 10, 20 mg/kg, intraperitoneal) Angipars and vehicle for 2 weeks. At the end of the eighth week, the control and treated rats were examined through the hot plate and tail flick tests. ANOVA was used to evaluate the statistical difference and P<0.05 was considered as significant.

Results: At the end of the eighth week, the response time to thermal hyperalgesia decreased in the vehicle and sham groups compared with the control group. Angipars at doses of 5 and 10 mg increased the response time to thermal hyperalgesia compared to the vehicle and sham groups in hot plate test. In the tail flick test, 10mg Angipars increased the response time to pain similar to the control group.

Conclusion: This study showed that, as an antioxidant, Angipars is capable of reducing neuropathic hyperalgesia in animals with diabetes.

Keywords: Diabetic Neuropathies – Rats - Pain
Citation: Zangiabadi N, Jafari M, Shaabani M. Effect of Angipars on neuropathic pain in streptozotocin-induced diabetic rats. Hormozgan Medical Journal 2015;19(4):231-236.
Full-Text [PDF 685 kb]   (365 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/02/15 | Accepted: 2016/02/15 | Published: 2016/02/15

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