Volume 13, Number 4 (Winter 2010)                   hmj 2010, 13(4): 227-233 | Back to browse issues page


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Solati S, Forooz Asadi M, Dehghani Zahedani M, Evazi M, Kamali M. Evaluation of endocrine dysfunction in thalassemia intermedia. hmj. 2010; 13 (4) :227-233
URL: http://hmj.hums.ac.ir/article-1-148-en.html

Assistant Professor Department of Internal Medicine
Abstract:   (8813 Views)
Introduction: Thalassemia is an inherited disease which leads to an imbalance of globinchain synthesis and consequently, ineffective hematopoiesis. Iron deposits in many important body organs, as endocrine organs due to blood transfusion or ineffective hematopoiessis. The aim of the present study is to assess the endocrine disorders in the patients with thalassemia intermedia referred to the thalassemia center of Bandar-Abbas, Iran.
Methods: Eighty-six patients with intermediate thalassemia attended the thalassemia center of Bandar-Abbas were enrolled in a cross-sectional, descriptive-analytic study. They were evaluated for demographic characteristics, past medical history, familial history and physically examined for sexual maturity and thyroid gland weight assessment. Then blood samples were taken to measure thyroid, parathyroid and sexual hormones. Fasting blood glucose, magnesium and ferritin levels were checked and were analyzed by SPSS 16.0.
Results: There were 47 males (54.7%) and 39 females (45.3%). Frequency of hypoparathyroidism was 18.6%, diabetes mellitus 8.1%, sub-clinical hypothyroidism 4.65%, hypo-phosphatemia 29.06%, and hypo-magnesemia was 1.16%. Delayed puberty was found in 6.07% girls and, 4.7% boys. Primary amenorrhea was seen in 15.4% of female cases. Moreover, there was not a significant difference in hemoglobin rate between hypoparalhyaism and normal cases (P<0.05).
Conclusion: It's recommended to evaluate the patients' suffering from thalassemia intermedia for diabetes mellitus, thyroid dysfunctions, parathyroid abnormality, and sexual maturity routinely.
Full-Text [PDF 217 kb]   (976 Downloads)    
Type of Study: Research | Subject: General
Received: 2012/10/19

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