Volume 15, Number 2 (Summer 2011)                   hmj 2011, 15(2): 74-89 | Back to browse issues page


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Noori Daloii M, Alizadeh F. Prognostic molecular markers in hepatocellular carcinoma (Review article. hmj. 2011; 15 (2) :74-89
URL: http://hmj.hums.ac.ir/article-1-81-en.html

Professor Department of Medical Ge
Abstract:   (9983 Views)
Hepatocellular carcinoma (HCC) is the 5th commonest malignancy worldwide and is the third most common cause of cancer-related death. The prevalence is different in the world. The ability to predict patients at higher risk of recurrence and with a poor prognosis would help to guide surgical and chemotherapeutic treatment according to individual risk. As understanding of hepatocarcinogenesis has increased, the myriad of genetic and molecular events that drive the hepatocarcinogenic disease process, including angiogenesis, invasion and metastasis, have been identified. With advances in understanding of tumor biology, interest in molecular biomarkers of carcinogenesis has grown, both in terms of their prognostic significance and also their potential as therapeutic targets. Several molecular markers with prognostic significance have been identified in HCC. Not only these molecules may allow accurate prediction of prognosis of patients with HCC and allow targeting of therapy, but they may also represent novel targets for therapeutic agents. The aim of this review was to examine the current knowledge regarding the prognostic role of the most important molecular biomarkers in HCC. In this article prognostic value of the following molecular markers is discussed: tumor suppressor genes oncogenes cell cycle regulators apoptotic regulators markers of angiogenesis markers of invasion and metastasis growth factors and receptors telomerase markers of genomic instability aneuploidy and markers of microsatellite instability.
Full-Text [PDF 442 kb]   (1201 Downloads)    
Type of Study: Research | Subject: General
Received: 2012/10/18

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