Volume 20, Number 2 (6-2016)                   hmj 2016, 20(2): 73-82 | Back to browse issues page


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Jarineshin H, Fekrat F, Kashani S. Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia. hmj. 2016; 20 (2) :73-82
URL: http://hmj.hums.ac.ir/article-1-1580-en.html

Department of Anesthesiology
Abstract:   (1042 Views)

Introduction: Nausea and vomiting is one of the complications of spinal anesthesia in cesarean section. The aim of this study was to compare the effects of dexamethasone-metocloprmide with ondansetrone on preventing nausea and vomiting during spinal Anesthesia for cesarean section.

Methods: In this study 212 pregnant women (17-45 years old) candidate for elective cesarean section with an ASA I-II were subjected to a randomized double blind clinical trial. Before spinal anesthesia was applied the first group received 8 milligram dexamethasone and 10 milligram metoclopramide intravenously, the second group received 8 milligram ondansetrone intravenously.

Correspondence:

Saeed Kashani, MD.

Anesthesiology Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences.

Bandar Abbas, Iran

Tel:+98 9177614110

Email:

sdkashani468@gmail.com

Results: There were no significant differences between the two groups regarding the demographic variables, and also heart rate, systolic and diastolic blood pressures at before neuroaxial block and at 1, 3, 5 and 10 minutes after block. )P>0.05). The Apgar score between the two groups was significantly different at the first (P=0.028), fifth (P=0.001) and twentieth minute (P=0.019). The overall incidence of nausea was 11.3% with no significant difference between the groups (P=0.665). No patient in the dexamethasone-metocloprimde group experienced any vomiting and in the ondansetrone group only 5 patients (4.7%) had vomiting (P>0.05).

Conclusion: The combination of dexamethasone and metocloprimde is effective in preventing nausea and vomiting during cesarean section in women who have no other pregnancy related complications

Keywords: Metoclopramide, Vomiting, Ondansetron, Spinal Anesthesia
Citation: Jarineshin H, Fekrat F, Kashani S. Comparison of the effect of Dexamethasone - Metoclopramide combination and ondansetron in the prevention of nausea and vomiting in cesarean section under spinal Anesthesia. Hormozgan Medical Journal 2016;20(2):73-82.
Full-Text [PDF 771 kb]   (457 Downloads)    
Type of Study: Research | Subject: medical
Received: 2016/09/13 | Accepted: 2016/09/13 | Published: 2016/09/13

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