Volume 19, Issue 6 (2-2016)                   hmj 2016, 19(6): 457-461 | Back to browse issues page

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Hyperreactio Luteinalis with early-onset HELLP syndrome: A case report. hmj. 2016; 19 (6) :457-461
URL: http://hmj.hums.ac.ir/article-1-1556-en.html
Abstract:   (2365 Views)

Introduction: Hyperreactio Luteinalis (HL) is a rare benign condition in pregnancy which is characterized by bilaterally multicystic ovarian enlargement containing theca lutein cysts caused by increased production of hCG. HL is mostly associated with hydatidiform mole and multiple pregnancies.


Azin Alavi, MD.

Hormozgan Feritiliy and Infertility Research Center, Hormozgan University of Medical Sciences.

Bandar Abbas, Iran

Tel:+98 917 3615827



Case Report: We report a unique case of hyperreactio Luteinalis (HL) in spontaneous singleton pregnancy with elevated level of human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) for who referred to our center for high blood pressure and proteinuria which subsequently developed early–onset HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) at 18 weeks of pregnancy. Termination of pregnancy was considered and a patient passed a normal dead fetus. Placental histology showed evidence of hypoperfusion with focal villous infarction and ischemic changes without evidence of trophoblastic abnormalities.

Conclusion: Hyperreactio luteinalis associating with high level of hCG in second trimester can be consequence of inadequate trophoblast invasion and may be a risk factor for early onset HELLP syndrome

Full-Text [PDF 336 kb]   (713 Downloads)    
Type of Study: Research | Subject: medical
Received: 2016/06/7 | Accepted: 2016/06/7 | Published: 2016/06/7

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