Volume 19, Number 6 (2-2016)                   hmj 2016, 19(6): 407-412 | Back to browse issues page


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Motamedi Rad N, Rezaeishamirzadi M, Moosavy S H, Shekari M. Evaluation of frequency polymorphism Interleukin 1B gene in patients with peptic ulcer and chronic gastritis. hmj. 2016; 19 (6) :407-412
URL: http://hmj.hums.ac.ir/article-1-1551-en.html

Abstract:   (1081 Views)

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only 20% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-1B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-1B gene.

Methods: 107 individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-1B+3954C/T polymorphism was analyzed through PCR-RFLP.

Results: There is no association between the presence of the T allele in an IL-1B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=0.66, CI=0.34-1.27, OR=0.75, CI=0.32-1.15) respectively.

Conclusion: Our results suggest that there is no association between IL-1B+3954 C/T polymorphism and peptic ulcer disease and chronic inflammation.

Full-Text [PDF 595 kb]   (278 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/06/1 | Accepted: 2016/06/1 | Published: 2016/06/1

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