Volume 19, Number 4 (11-2015)                   hmj 2015, 19(4): 237-244 | Back to browse issues page


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Bagherizadeh T, Gol A, Olomi H. Effect of Citrullus Colocynthis pulp on renal function in streptozotocin-induced diabetic rats. hmj. 2015; 19 (4) :237-244
URL: http://hmj.hums.ac.ir/article-1-1521-en.html

Department of Biology
Abstract:   (1213 Views)

Introduction: Diabetic nephropathy is one of the most serious microvascular complications of diabetes and the main cause of end-stage renal disease. Various herbs have been used to control diabetes complications. This study aimed at investigating the effect of Citrullus colocynthis pulp on diabetes-induced renal damage in male rats.

Correspondence:

A. Gol, PhD.

Department of Biology. Kerman University of Medical Sciences.

Kerman, Iran

Tel:+98 9132990713

Email:

agol@mail.uk.ac.ir

Methods: A total of 36 rats were divided into 6 groups: 1- normal (N), 2- normal + 10 mg/kg colocynth (N+C10), 3- normal + 30 mg/kg colocynth (N+C30), 4- diabetic (D), 5- diabetic+10 mg/kg colocynth (D+C10), and 6- diabetic+30 mg/kg colocynth (D+C30). The rats received colocynth pulp through gavage for two weeks. The obtained data were analyzed through ANOVA and Tukey test using SPSS 16.

Results: The diabetic rats showed a sharp rise in the volume of urine, clearance of albumin, clearance of creatinine, and serum urea. Administration of colocynth in diabetic rats improved the changes to normal.

Conclusion: The results of this study show that colocynth pulp has the potential to treat diabetes and to prevent the relevant kidney damages.

Keywords: Diabetes Mellitus - Citrullus Colocynthis - Rat
Citation: Bagherizadeh T, Gol A, Olomi H. Effect of Citrullus Colocynthis pulp on renal function in streptozotocin-induced diabetic rats. Hormozgan Medical Journal 2015;19(4):237-244.
Full-Text [PDF 935 kb]   (423 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/02/17 | Accepted: 2016/02/17 | Published: 2016/02/17

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