Volume 19, Number 2 (6-2015)                   hmj 2015, 19(2): 103-110 | Back to browse issues page


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Ostovan F, Gol A. Effects of Colocynth (Citrullus colocynthis) Pulp on Serum Levels of Testosterone and Changes in Reproductive Organs in Streptozotocin-Induced Diabetic Rats. hmj. 2015; 19 (2) :103-110
URL: http://hmj.hums.ac.ir/article-1-1471-en.html

Department of Biology
Abstract:   (1418 Views)

Introduction: Investigating the effects of colocynth pulp on levels of testosterone and changes in the reproductive system organs in streptozotocin-induced diabetic rats. Methods: In this study, 32 Wistar rats were divided into four groups of normal (N), normal+colocynth pulp (N+C), diabetic control (D), and diabetic+colocynth pulp (D+C). Groups N and D received orally 2 mL normal saline for two weeks, and groups N+C and D+C received orally 10 mg/kg colocynth pulp for two weeks. Diabetes was induced in rats through intraperitoneal injection of 65 mg/kg streptozotocin (STZ). Results: Group D showed a significant increase in glucose levels compared with Group N (P<0.0001), and testosterone levels, body weight, and reproductive organs weight ratio of group D decreased significantly compared with Group N (P<0.0001). In addition, a significant reduction in glucose level (P<0.01) and a significant increase in testosterone level and reproductive organs weight ratio (P<0.01) were observed in Group D+C in comparison to Group D. Conclusion: This study showed that consumption of 10 mg/kg colocynth for two weeks relatively improved glucose and testosterone levels as well as reproductive system damage in streptozotocin-induced diabetes in rats.

Keywords: Diabetes – Streptozotocin – Testosterone
Citation: Ostovan F, Gol A. Effects of Colocynth (Citrullus colocynthis) Pulp on Serum Levels of Testosterone and Changes in Reproductive Organs in Streptozotocin-Induced Diabetic Rats. Hormozgan Medical Journal 2015;19(2):103-110.
Full-Text [PDF 373 kb]   (522 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/08/17 | Accepted: 2015/08/17 | Published: 2015/08/17

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