Volume 13, Number 4 (Winter 2010)                   hmj 2010, 13(4): 213-218 | Back to browse issues page


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Assar O, Bagheri J, Mehraeen A, Jaebelli M, Mandegar M. Administration of aminophylline as a myocardial protective in CABG operation. hmj. 2010; 13 (4) :213-218
URL: http://hmj.hums.ac.ir/article-1-146-en.html

Assistant Professor Department of Cardiac Surgery
Abstract:   (6211 Views)
Introduction: Myocardial protection is one of the most important determinants of the result of CABG operation. The benefit of aminophylline has been proved in addition to antegrade cardioplegia but has not been studied plus Antegrade and retrograde cardioplegia. This study was designed to evaluate the effects of aminophyliine as a cardioprotective agent for patients undergoing on-pump CABG with antegrade and retrograde cardioplegia.
Methods: In this double-blinded randomized clinical trial, 40 patients were randomly assigned to receive either IV aminophylline (5,g/kg) (n=20) or saline (n=20) before anesthesia induction. Troponin T level was measured 30 minuets, 2 hours and 24 hours after aortic clamping. For data analysis, t-test, chi-square and Mann-Whitney test was used.
Results: Troponin T level was significantly lower in aminophylline group 30 minutes (P=0.03) and 2 hours (P=0.01) after aortic cross clamp. No difference was observed with clinical Parameters.
Conclusion: Pretreatment with aminophylline reduces myocardial injury at sub-clinical level, particularly to benefit the ante-retrograde cardioplegia alone.
Full-Text [PDF 205 kb]   (628 Downloads)    
Type of Study: Research | Subject: General
Received: 2012/10/19

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