Volume 18, Number 5 (12-2014)                   hmj 2014, 18(5): 357-369 | Back to browse issues page


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Moshfegh A, Yarabi A, Tehranifard A, Dastan K. Involvement of α-1-adrenergic receptors in central region of amygdala and the effects of cannabinoid agonist on inhibitory avoidance memory in male rats. hmj. 2014; 18 (5) :357-369
URL: http://hmj.hums.ac.ir/article-1-1388-en.html

Department of Biology
Abstract:   (1092 Views)

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by Cannabinoids. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of α-1-adrenergic receptors in central region of amygdala in state-dependent learning induced by WIN55,212-2 (cannabinoid agonist) in rats. Methods: Cannulae placement was performed bilaterally in the central amygdala region of male rats. The rats were trained in the avoidance learning apparatus (step-down model). 24 hours after training, the memory was tested by measuring the lag time for stepping down the platform. Results: Injection of WIN55, 212-2 intra central amygdala (dose-dependent, 0.25, 0.5 µg/rat) post-training reduced lag time/latency for stepping down. Injection induced amnesia was reversed by pre-test administration of the same dose of WIN55, 212-2. It is called state-dependent learning. Pre-test intra-central injection of α-1-adrenoceptor agonist, Phenylephrine (0.5, 0.25 µg/rat) improved post-training WIN55, 212-2 (0.5 µg/rat) intra central injection induced retrieval impairment. But intra injection of Prazosin (0.5 µg/rat) 2 minutes before injection of WIN55, 212-2 (0.5 µg/rat) on the testing day inhibited WIN55, 212-2 state-dependent learning. Conclusion: The results suggest that α-1-adrenergic receptors in central region of amygdala are involved in learning which dependent on the state induced by WIN55, 212-

Keywords: Cannabinoids - α1 - Adrenergic - Learning
Citation: Moshfegh A, Yarabi A.R, Tehranifard A, Dastan A. Involvement of α-1-adrenergic receptors in central region of amygdala and the effects of cannabinoid agonist on inhibitory avoidance memory in male rats. Hormozgan Medical Journal 2014;18(5):357-369.
Full-Text [PDF 799 kb]   (322 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/02/24 | Accepted: 2015/02/24 | Published: 2015/02/24

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